Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Metabolic switching of PI3K-dependent lipid signals.

Biochemical Society transactions - 1 Apr 2007

Downes C P, Leslie N R, Batty I H, van der Kaay J

Abstract excerpt

The lipid phosphatase, PTEN (phosphatase and tensin homologue deleted on chromosome 10), is the product of a major tumour suppressor gene that antagonizes PI3K (phosphoinositide 3-kinase) signalling by dephosphorylating the 3-position of the inositol ring of PtdIns(3,4,5)P(3). PtdIns(3,4,5)P(3) is also metabolized by removal of the 5-phosphate catalysed by a distinct family of enzymes exemplified by SHIP1 [SH2...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acid Anhydride Hydrolases
Share to Homeostasis
Share to Inositol Phosphates

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Leptin

Share to Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases

Share to Phosphatidylinositol 3-Kinases

Share to Phosphoric Monoester Hydrolases

Share to PTEN Phosphohydrolase

Source

Identifiers

PMID: 17371235
DOI: 10.1042/BST0350188

Genes

PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Metabolic switching of PI3K-dependent lipid signals.PMID 17371235Read ↗

The role of PTEN as a PI(3,4)P2 lipid phosphatase in Class I phosphoinositide 3-kinase signallingSemantic proximity Read ↗

Allosteric activation of PTEN phosphatase by phosphatidylinositol 4,5-bisphosphate.Semantic proximity Read ↗

The PTEN and Myotubularin phosphoinositide 3-phosphatases: linking lipid signalling to human disease.Semantic proximity Read ↗

The role of SHIP in cytokine-induced signaling.Semantic proximity Read ↗

PTEN: tumour suppressor, multifunctional growth regulator and more.Semantic proximity Read ↗

Mechanisms regulating phosphoinositide 3-kinase signalling in insulin-sensitive tissues.Semantic proximity Read ↗

Regulation of phosphoinositide metabolism, Akt phosphorylation, and glucose transport by PTEN (phosphatase and tensin homolog deleted on chromosome 10) in 3T3-L1 adipocytes.Semantic proximity Read ↗

Analysis of the cellular functions of PTEN using catalytic domain and C-terminal mutations: differential effects of C-terminal deletion on signalling pathways downstream of phosphoinositide 3-kinase.Semantic proximity Read ↗

Phosphatidylinositol-3,5-bisphosphate: metabolism and physiological functions.Semantic proximity Read ↗

Signalling by PI3K isoforms: insights from gene-targeted mice.Semantic proximity Read ↗

PTEN M-CBR3, a versatile and selective regulator of inositol 1,3,4,5,6-pentakisphosphate (Ins(1,3,4,5,6)P5). Evidence for Ins(1,3,4,5,6)P5 as a proliferative signal.Semantic proximity Read ↗

Lipid phosphatase SHIP2 functions as oncogene in colorectal cancer by regulating PKB activation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.