Article
Lipid phosphatase SHIP2 functions as oncogene in colorectal cancer by regulating PKB activation.
Oncotarget - 8 Nov 2016
Hoekstra Elmer, Das Asha M, Willemsen Marcella, Swets Marloes, Kuppen Peter J K, van der Woude Christien J, Bruno Marco J, Shah Jigisha P, Ten Hagen Timo L M, Chisholm John D, Kerr William G, Peppelenbosch Maikel P, Fuhler Gwenny M
Abstract excerpt
Colorectal cancer (CRC) is the second most common cause of cancer-related death, encouraging the search for novel therapeutic targets affecting tumor cell proliferation and migration. These cellular processes are under tight control of two opposing groups of enzymes; kinases and phosphatases. Aberrant activity of kinases is observed in many forms of cancer and as phosphatases counteract such "oncogenic" kinases,...
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