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Article

PTEN M-CBR3, a versatile and selective regulator of inositol 1,3,4,5,6-pentakisphosphate (Ins(1,3,4,5,6)P5). Evidence for Ins(1,3,4,5,6)P5 as a proliferative signal.

The Journal of biological chemistry - 9 Jan 2004

Orchiston Elaine A, Bennett Deborah, Leslie Nick R, Clarke Rosemary G, Winward Lucinda, Downes C Peter, Safrany Stephen T

Abstract excerpt

The PTEN (phosphatase and tensin homologue deleted on chromosome 10) tumor suppressor is a phosphatidylinositol 3,4,5-trisphosphate (PtdInsP3) 3-phosphatase that plays a crucial role in regulating many cellular processes by antagonizing the phosphoinositide 3-kinase signaling pathway. Although able to metabolize soluble inositol phosphates in vitro, the question of their significance as physiological substrates...

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Source

Identifiers

PMID: 14561749
DOI: 10.1074/jbc.M310933200

Genes

PTEN
CBR3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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PTEN M-CBR3, a versatile and selective regulator of inositol 1,3,4,5,6-pentakisphosphate (Ins(1,3,4,5,6)P5). Evidence for Ins(1,3,4,5,6)P5 as a proliferative signal.PMID 14561749Read ↗

Allosteric activation of PTEN phosphatase by phosphatidylinositol 4,5-bisphosphate.Semantic proximity Read ↗

The role of PTEN as a PI(3,4)P2 lipid phosphatase in Class I phosphoinositide 3-kinase signallingSemantic proximity Read ↗

Targeting phospshatidylinositol 3-kinase signaling with novel phosphatidylinositol 3,4,5-triphosphate antagonists.Semantic proximity Read ↗

PTEN Regulates PI(3,4)P2 Signaling Downstream of Class I PI3K.Semantic proximity Read ↗

Metabolic switching of PI3K-dependent lipid signals.Semantic proximity Read ↗

Inositol pyrophosphates as mammalian cell signals.Semantic proximity Read ↗

Novel functional PI 3‐kinase antagonists inhibit cell growth and tumorigenicity in human cancer cell linesSemantic proximity Read ↗

Phosphatidylinositol-3,5-bisphosphate: metabolism and physiological functions.Semantic proximity Read ↗

A novel phosphatidylinositol(3,4,5)P3 pathway in fission yeast.Semantic proximity Read ↗

PTEN counteracts FBXL2 to promote IP3R3- and Ca2+-mediated apoptosis limiting tumour growth.Semantic proximity Read ↗

The p85beta regulatory subunit of PI3K serves as a substrate for PTEN protein phosphatase activity during insulin mediated signaling.Semantic proximity Read ↗

Regulation of phosphoinositide metabolism, Akt phosphorylation, and glucose transport by PTEN (phosphatase and tensin homolog deleted on chromosome 10) in 3T3-L1 adipocytes.Semantic proximity Read ↗

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