Article
The association of human leukocyte antigen alleles with clinical disease progression in HIV-positive cohorts with varied treatment strategies.
AIDS (London, England) - 1 Apr 2021
Ekenberg Christina, Reekie Joanne, Zucco Adrian G, Murray Daniel D, Sharma Shweta, Macpherson Cameron R, Babiker Abdel, Kan Virginia, Lane H Clifford, Neaton James D, Lundgren Jens D
Abstract excerpt
OBJECTIVES: The Strategic Timing of AntiRetroviral Treatment (START) and Strategies for Management of Antiretroviral Therapy (SMART) trials demonstrated that ART can partly reverse clinically defined immune dysfunction induced by HIV replication. As control of HIV replication is influenced by the HLA region, we explored whether HLA alleles independently influence the risk of clinical events in HIV+ individuals....
Topics
- Alleles
- Cohort Studies
- Disease Progression
- HIV Infections
- HIV-1
- HLA Antigens
- Humans