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Article

The <i>Telomerase Reverse Transcriptase</i> (<i>hTERT</i>) Gene Is a Direct Target of the Histone Methyltransferase SMYD3

15 Mar 2007

Abstract excerpt

Recent evidence has accumulated that the dynamic histone methylation mediated by histone methyltransferases and demethylases plays key roles in regulation of chromatin structure and transcription. In the present study, we show that SET and MYND domain-containing protein 3 (SMYD3), a histone methyltransferase implicated in oncogenesis, directly trans-activates the telomerase reverse transcriptase (hTERT) gene that...

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Share to Epigenetics and DNA Methylation
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PMID: 17363582
DOI: 10.1158/0008-5472.can-06-4126

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