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Article

Understanding and exploiting <i>hTERT</i> promoter regulation for diagnosis and treatment of human cancers

1 Aug 2008

Abstract excerpt

Telomerase activation is a critical step for human carcinogenesis through the maintenance of telomeres, but the activation mechanism during carcinogenesis remains unclear. Transcriptional regulation of the human telomerase reverse transcriptase (hTERT) gene is the major mechanism for cancer-specific activation of telomerase, and a number of factors have been identified to directly or indirectly regulate the hTERT...

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Share to Advanced biosensing and bioanalysis techniques
Share to Telomeres, Telomerase, and Senescence
Share to Virus-based gene therapy research

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Identifiers

PMID: 18754863
DOI: 10.1111/j.1349-7006.2008.00878.x

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