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Article

Telomerase reverse transcriptase regulates DNMT3B expression/aberrant DNA methylation phenotype and AKT activation in hepatocellular carcinoma.

Cancer letters - 10 Oct 2018

Yu Jingya, Yuan Xiaotian, Sjöholm Louise, Liu Tiantian, Kong Feng, Ekström Tomas J, Björkholm Magnus, Xu Dawei

Abstract excerpt

Telomerase reverse transcriptase (TERT)1 acts as a master regulator of cancer hallmarks, but underlying mechanisms remain incompletely understood. We show that TERT is required for the aberrant DNA methyltransferase 3 B (DNMT3B)2 expression and cancer-specific methylation in hepatocellular carcinoma (HCC)3, through which AKT is activated. TERT depletion inhibited, while its over-expression promoted DNMT3B...

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Share to Carcinoma, Hepatocellular
Share to DNA (Cytosine-5-)-Methyltransferases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Methyltransferase 3B

Share to Proto-Oncogene Proteins c-akt

Share to PTEN Phosphohydrolase

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Source

Identifiers

PMID: 30017965
DOI: 10.1016/j.canlet.2018.07.013

Genes

TERT
PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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