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Article

Hypermethylation of the human telomerase catalytic subunit (<i>hTERT</i>) gene correlates with telomerase activity

29 Aug 2002

Abstract excerpt

DNA methylation is an epigenetic process involved in embryonic development, differentiation and aging. It is 1 of the mechanisms resulting in gene silencing in carcinogenesis, especially in tumor suppressor genes (e.g., p16, Rb). Telomerase, the DNA polymerase adding TTAGGG repeats to the chromosome end, is involved in the regulation of the replicative life span by maintaining telomere length. This enzyme is...

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Share to Epigenetics and DNA Methylation
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PMID: 12209957
DOI: 10.1002/ijc.10593

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Hypermethylation of the human telomerase catalytic subunit (<i>hTERT</i>) gene correlates with telomerase activityPMID 12209957Read ↗

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