Article
Smyd3 regulates cancer cell phenotypes and catalyzes histone H4 lysine 5 methylation.
Epigenetics - 1 Apr 2012
Van Aller Glenn S, Reynoird Nicolas, Barbash Olena, Huddleston Michael, Liu Shichong, Zmoos Anne-Flore, McDevitt Patrick, Sinnamon Robert, Le BaoChau, Mas Gloria, Annan Roland, Sage Julien, Garcia Benjamin A, Tummino Peter J, Gozani Or, Kruger Ryan G
Abstract excerpt
Smyd3 is a lysine methyltransferase implicated in chromatin and cancer regulation. Here we show that Smyd3 catalyzes histone H4 methylation at lysine 5 (H4K5me). This novel histone methylation mark is detected in diverse cell types and its formation is attenuated by depletion of Smyd3 protein. Further, Smyd3-driven cancer cell phenotypes require its enzymatic activity. Thus, Smyd3, via H4K5 methylation, provides...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.