Downstream E-Box–mediated Regulation of the Human Telomerase Reverse Transcriptase (<i>hTERT</i>) Gene Transcription: Evidence for an Endogenous Mechanism of Transcriptional Repression

Abstract excerpt

Regulation of the hTERT gene encoding the telomerase catalytic subunit plays an important role in human cell senescence, immortalization, and carcinogenesis. By examining the activity of various deleted or mutated hTERT promoter fragments, we show that an E-box element downstream of the transcription initiation site is critical to differential hTERT transcription between the telomerase/hTERT-positive renal cell...

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• Share to Chromosomal and Genetic Variations
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