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Article

Poly (ADP-ribose) polymerase-1 (PARP-1) genetic variants are protective against Parkinson's disease.

Journal of the neurological sciences - 15 May 2007

Infante Jon, Sánchez-Juan Pascual, Mateo Ignacio, Rodríguez-Rodríguez Eloy, Sánchez-Quintana Coro, Llorca Javier, Fontalba Ana, Terrazas Jesús, Oterino Agustín, Berciano José, Combarros Onofre

Abstract excerpt

Poly (ADP-ribose) polymerase-1 (PARP-1) is involved in crucial pathogenic events in Parkinson's disease (PD). We studied the effect of promoter variations of PARP-1 gene on the risk for PD in a case-control association study comprising 146 PD patients and 161 controls from Northern Spain. Three polymorphisms from the promoter region of PARP-1 gene were analyzed: -410C/T, -1672G/A, and a (CA)n microsatellite. A...

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PMID: 17362997
DOI: 10.1016/j.jns.2007.02.008

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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