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Article

The impacts of prominent gene polymorphisms in DNA repair enzymes on Parkinson's disease.

Neuroscience letters - 14 Sept 2020

Aslan Nergis Selma, Orhan Gürdal, Karahalil Bensu

Abstract excerpt

Parkinson's Disease (PD), a chronic and progressive neurodegenerative disease of the brain, is associated with the loss of dopaminergic neurons. Its pathogenesis remains unclear; however, oxidative DNA damage due to reactive oxygen species (ROS) is believed to play a major role in the etiology of PD. DNA repair systems can mitigate oxidative DNA damage and help to maintain genomic stability and thus prevent...

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PMID: 32603833
DOI: 10.1016/j.neulet.2020.135203

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