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Interaction between poly(ADP-ribose) polymerase 1 and interleukin 1A genes is associated with Alzheimer's disease risk.

Dementia and geriatric cognitive disorders - 1 Jan 2007

Infante Jon, Llorca Javier, Mateo Ignacio, Rodríguez-Rodríguez Eloy, Sánchez-Quintana Coro, Sánchez-Juan Pascual, Fernández-Viadero Carlos, Peña Nicolás, Berciano José, Combarros Onofre

Abstract excerpt

Excessive release of proinflammatory cytokines by activated microglia surrounding senile plaques might contribute to the neurodegeneration associated with Alzheimer's disease (AD). Poly(ADP-ribose) polymerase 1 (PARP-1) is a nuclear protein recently implicated in the initial inflammatory response by modulating expression of inflammation-related genes, like interleukin 1 (IL-1). As PARP-1 overactivity has been...

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PMID: 17290104
DOI: 10.1159/000099471

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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