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Article

Analysis of genetic variants of the poly(ADP-ribose) polymerase-1 gene in breast cancer in French patients.

Mutation research - 15 Aug 2007

Cao Wen-Hui, Wang Xiaogan, Frappart Lucien, Rigal Dominique, Wang Zhao-Qi, Shen Yan, Tong Wei-Min

Abstract excerpt

Poly(ADP-ribose) polymerase-1 (PARP-1) is a nuclear enzyme that catalyzes the poly(ADP-ribosyl)ation of target proteins in response to DNA damage and has been proposed to play a role in DNA repair, recombination, transcription, cell death, cell proliferation, as well as in stabilization of the genome. We have recently shown that PARP-1 deficiency causes mammary tumorigenesis in mice. In the present study, we...

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PMID: 17560163
DOI: 10.1016/j.mrgentox.2007.04.011

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Analysis of genetic variants of the poly(ADP-ribose) polymerase-1 gene in breast cancer in French patients.PMID 17560163Read ↗

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