Article
Leu54Phe and Val762Ala polymorphisms in the poly(ADP-ribose)polymerase-1 gene are associated with diabetic polyneuropathy in Russian type 1 diabetic patients.
Diabetes research and clinical practice - 1 Mar 2008
Nikitin Alexey G, Chudakova Dariya A, Strokov Igor A, Bursa Tamara R, Chistiakov Dimitry A, Nosikov Valery V
Abstract excerpt
Poly(ADP-ribose) polymerase-1 (PARP-1) is an ubiquitous DNA-binding protein involved in the cellular response to various genotoxic agents. Excessive PARP-1 activation is known to lead to the depletion of intracellular NAD+ and ATP pools and hence to threat cell survival. Therefore, PARP-1 could be involved in neuronal death and contribute to the development of diabetic polyneuropathy (DPN). This study addressed...
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