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Article

Association analysis of PARP1 polymorphisms with Parkinson's disease.

Parkinsonism & related disorders - 1 Nov 2011

Brighina Laura, Riva Chiara, Bertola Francesca, Fermi Silvia, Saracchi Enrico, Piolti Roberto, Goldwurm Stefano, Pezzoli Gianni, Ferrarese Carlo

Abstract excerpt

Alpha-synuclein accumulation in intracellular inclusions, oxidative stress and microglia-mediated inflammation in the substantia nigra are crucial events in the pathogenesis of Parkinson's disease (PD). Poly (ADP-ribose) polymerase-1 (PARP1), a DNA-binding enzyme and transcriptional regulator, plays an important role in modulating the cellular response to oxidative stress, inflammatory stimuli, and in apoptotic...

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Source

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Identifiers

PMID: 21767974
DOI: 10.1016/j.parkreldis.2011.06.022
PMCID: PMC3254239

Genes

PARP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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