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Article

Evaluation of the poly(ADP-ribose) polymerase-1 gene variants in Alzheimer's disease.

Journal of clinical laboratory analysis - 1 Jan 2010

Liu Hsin-Ping, Lin Wei-Yong, Wu Bor-Tsang, Liu Shu-Hsiang, Wang Wen-Fu, Tsai Chon-Haw, Lee Chun-Cheng, Tsai Fuu-Jen

Abstract excerpt

Amyloid peptide is thought to play a critical role in neuronal death in Alzheimer's disease (AD), most likely through oxidative stress. Free radical-related injury leads to DNA breaks, which subsequently activates the repair enzyme poly(ADP-ribose) polymerase-1 (PARP-1). In this study, the relati...

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Identifiers

PMID: 20486200
DOI: 10.1002/jcla.20379
PMCID: PMC6647671

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20486200-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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