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Article

Expression and Single Nucleotide Polymorphism of Poly (ADPRibose) Polymerase-1 in Gastrointestinal Tumours: Clinical Involvement.

Current medicinal chemistry - 1 Jan 2017

Martín-Guerrero Sandra M, León Josefa, Quiles-Perez Rosa, Belmonte Laura, Martin-Oliva David, Ruiz-Extremera Ángeles, Salmerón Javier, Muñoz-Gámez José Antonio

Abstract excerpt

Poly(ADP-ribose) polymerase-1 (PARP-1) is a nuclear enzyme that plays a critical role in diverse cellular functions, such as DNA damage detection and repair, transcriptional regulation and cell death. Furthermore, PARP-1 has emerged as a key player in the pathogenesis of multiple inflammatory diseases and has become a promising target for the treatment of cardiovascular disorders, neurodegenerative diseases and...

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Identifiers

PMID: 28302009
DOI: 10.2174/0929867324666170316115039

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