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Article

Identification of the TPO1 gene in yeast, and its human orthologue TETRAN, which cause resistance to NSAIDs.

FEBS letters - 3 Apr 2007

Mima Shinji, Ushijima Hironori, Hwang Hyun-Jung, Tsutsumi Shinji, Makise Masaki, Yamaguchi Yoshihiro, Tsuchiya Tomofusa, Mizushima Hiroshi, Mizushima Tohru

Abstract excerpt

Non-steroidal anti-inflammatory drugs (NSAIDs), such as indomethacin, have serious gastrointestinal side effects. Since their direct cytotoxicity was suggested to be involved in this side effect, we here tried to identify NSAID-resistant genes. We screened for Saccharomyces cerevisiae genes whose overexpression causes indomethacin resistance and identified the TPO1 gene, which encodes a major facilitator...

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PMID: 17362938
DOI: 10.1016/j.febslet.2007.03.001

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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