Article
Identification of yeast and human 5-aminoimidazole-4-carboxamide-1-β-d-ribofuranoside (AICAr) transporters.
The Journal of biological chemistry - 13 Jun 2014
Ceschin Johanna, Saint-Marc Christelle, Laporte Jean, Labriet Adrien, Philippe Chloé, Moenner Michel, Daignan-Fornier Bertrand, Pinson Benoît
Abstract excerpt
5-Aminoimidazole-4-carboxamide-1-β-d-ribofuranoside (AICAr) is the precursor of the active monophosphate form (AICAR), a small molecule with potent anti-proliferative and low energy mimetic properties. The molecular bases for AICAR toxicity at the cellular level are poorly understood. Here, we report the isolation and characterization of several yeast AICAr-hypersensitive mutants. Identification of the cognate...
Topics
- Aminoimidazole Carboxamide
- Animals
- Cell Line
- Cell Line, Tumor
- Humans
- Membrane Transport Proteins
- Mice
- Mutation
- Nucleoside Transport Proteins
- Ribonucleotides
- Saccharomyces cerevisiae
- Saccharomyces cerevisiae Proteins
- Thiamine