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Article

The SNQ3 gene of Saccharomyces cerevisiae confers hyper-resistance to several functionally unrelated chemicals.

Current genetics - 1 Jun 1991

Hertle K, Haase E, Brendel M

Abstract excerpt

A multi-copy plasmid containing the SNQ3 gene confers hyper-resistance to 4-nitroquinoline-N-oxide (4NQO), Trenimon, MNNG, cycloheximide, and to sulfometuron methyl in yeast transformants. Restriction analysis, subcloning, and DNA sequencing revealed an open reading frame of 1,950 bp on the SNQ3-containing insert DNA. Gene disruption and transplacement into chromosomal DNA yielded 4NQO-sensitive null mutants...

Topics

Amino Acid Sequence
Antifungal Agents
Base Sequence
Cloning, Molecular
Drug Resistance, Microbial
Gene Expression Regulation, Fungal
Genes, Fungal
Molecular Sequence Data
Phenotype
Saccharomyces cerevisiae

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Identifiers

PMID: 1878996
DOI: 10.1007/BF00312733

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1878996-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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