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Article

Thiazole Antibiotics Target FoxM1 and Induce Apoptosis in Human Cancer Cells

15 May 2009

Abstract excerpt

Forkhead box M1 (FoxM1) oncogenic transcription factor represents an attractive therapeutic target in the fight against cancer, because it is overexpressed in a majority of human tumors. Recently, using a cell-based assay system we identified thiazole antibiotic Siomycin A as an inhibitor of FoxM1 transcriptional activity. Here, we report that structurally similar thiazole antibiotic, thiostrepton also inhibits...

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PMID: 19440351
DOI: 10.1371/journal.pone.0005592

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