Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Discovering thiamine transporters as targets of chloroquine using a novel functional genomics strategy.

PLoS genetics - 1 Jan 2012

Huang Zhiwei, Srinivasan Sankaranarayanan, Zhang Jianhuai, Chen Kaifu, Li Yongxiang, Li Wei, Quiocho Florante A, Pan Xuewen

Abstract excerpt

Chloroquine (CQ) and other quinoline-containing antimalarials are important drugs with many therapeutic benefits as well as adverse effects. However, the molecular targets underlying most such effects are largely unknown. By taking a novel functional genomics strategy, which employs a unique combination of genome-wide drug-gene synthetic lethality (DGSL), gene-gene synthetic lethality (GGSL), and dosage...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antimalarials
Share to Biological Transport

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chloroquine

Share to Genomics

Share to Membrane Transport Proteins

Share to Nucleoside Transport Proteins

Share to Saccharomyces cerevisiae Proteins

Share to Thiamine

Source

Open in PubMed Open full text

Identifiers

PMID: 23209439
DOI: 10.1371/journal.pgen.1003083
PMCID: PMC3510038

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Discovering thiamine transporters as targets of chloroquine using a novel functional genomics strategy.PMID 23209439Read ↗

The antimalarial drug quinine disrupts Tat2p-mediated tryptophan transport and causes tryptophan starvation.Semantic proximity Read ↗

<i>Plasmodium falciparum</i> quinine resistance is multifactorial and includes a role for the drug/metabolite transporters PfCRT and DMT1Semantic proximity Read ↗

Antitrypanosomal 8-Hydroxy-Naphthyridines Are Chelators of Divalent Transition Metals.Semantic proximity Read ↗

Heterologous Expression of a Novel Drug Transporter from the Malaria Parasite Alters Resistance to Quinoline Antimalarials.Semantic proximity Read ↗

A widespread role for SLC transmembrane transporters in resistance to cytotoxic drugsSemantic proximity Read ↗

Transcriptomic analysis of benznidazole-resistant Trypanosoma cruzi clone reveals nitroreductase I-independent resistance mechanismsSemantic proximity Read ↗

The malaria parasite's chloroquine resistance transporter is a member of the drug/metabolite transporter superfamily.Semantic proximity Read ↗

Inhibition of Thiamine Diphosphate-Dependent Enzymes by Triazole-Based Thiamine AnaloguesSemantic proximity Read ↗

Identification of yeast and human 5-aminoimidazole-4-carboxamide-1-β-d-ribofuranoside (AICAr) transporters.Semantic proximity Read ↗

Transcriptomic analysis of benznidazole-resistant <i>Trypanosoma cruzi</i> clone reveals nitroreductase I-independent resistance mechanismsSemantic proximity Read ↗

Genome-wide RNAi screens in bloodstream form trypanosomes identify drug transportersSemantic proximity Read ↗

Chloroquine resistance modulated in vitro by expression levels of the Plasmodium falciparum chloroquine resistance transporter.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.