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Article

Characterizing the laulimalide-peloruside binding site using site-directed mutagenesis of TUB2 in S. cerevisiae.

Molecular bioSystems - 1 Jan 2014

Hanna Reem, Maass David R, Atkinson Paul H, Northcote Peter T, Teesdale-Spittle Paul H, Bellows David S, Miller John H

Abstract excerpt

Baker's yeast, Saccharomyces cerevisiae, has significant sequence conservation with a core subset of mammalian proteins and can serve as a model for disease processes. The aim of this study was to determine whether yeast could be used as a model system to identify new agents that interact with the laulimalide-peloruside binding site on β-tubulin. Agents that bind to this site cause stabilization of microtubules...

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PMID: 24161989
DOI: 10.1039/c3mb70380k

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Characterizing the laulimalide-peloruside binding site using site-directed mutagenesis of TUB2 in S. cerevisiae.PMID 24161989Read ↗

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