Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Novel target genes of the yeast regulator Pdr1p: a contribution of the TPO1 gene in resistance to quinidine and other drugs.

Gene - 11 Jul 2001

do Valle Matta M A, Jonniaux J L, Balzi E, Goffeau A, van den Hazel B

Abstract excerpt

The yeast transcription factor Pdr1p regulates the expression of a number of genes, several of which encode ATP-driven transport proteins involved in multiple drug resistance. Among 20 genes containing binding consensus sequences for the transcription factor Pdr1p in their promoter, we studied more particularly the regulation and function of PDR16 (involved in phospholipid synthesis), TPO1 (involved in vacuolar...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Blotting, Northern
Share to Drug Resistance, Microbial

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Fungal Proteins

Share to Gene Expression Regulation, Fungal

Share to Lac Operon

Share to Quinidine

Share to Spermine

Share to Trans-Activators

Source

Identifiers

PMID: 11470516
DOI: 10.1016/s0378-1119(01)00558-3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Novel target genes of the yeast regulator Pdr1p: a contribution of the TPO1 gene in resistance to quinidine and other drugs.PMID 11470516Read ↗

Molecular and phenotypic characterization of yeast PDR1 mutants that show hyperactive transcription of various ABC multidrug transporter genes.Semantic proximity Read ↗

The transporters Pdr5p and Snq2p mediate diazaborine resistance and are under the control of the gain-of-function allele PDR1-12.Semantic proximity Read ↗

Differential display analysis of mutants for the transcription factor Pdr1p regulating multidrug resistance in the budding yeast.Semantic proximity Read ↗

Mutations in the yeast PDR3, PDR4, PDR7 and PDR9 pleiotropic (multiple) drug resistance loci affect the transcript level of an ATP binding cassette transporter encoding gene, PDR5.Semantic proximity Read ↗

Zinc cluster protein Rdr1p is a transcriptional repressor of the PDR5 gene encoding a multidrug transporter.Semantic proximity Read ↗

Yeast gene YRR1, which is required for resistance to 4-nitroquinoline N-oxide, mediates transcriptional activation of the multidrug resistance transporter gene SNQ2.Semantic proximity Read ↗

Competitive promoter occupancy by two yeast paralogous transcription factors controlling the multidrug resistance phenomenon.Semantic proximity Read ↗

A general strategy to uncover transcription factor properties identifies a new regulator of drug resistance in yeast.Semantic proximity Read ↗

The effects of transcription regulating genes PDR1, pdr1-3 and PDR3 in pleiotropic drug resistance.Semantic proximity Read ↗

Responses of Pathogenic and Nonpathogenic Yeast Species to Steroids Reveal the Functioning and Evolution of Multidrug Resistance Transcriptional NetworksSemantic proximity Read ↗

PDR2 Gain-of-function mutations eliminate the need for Pdr1 and require the UBP6 product for resistance to translational inhibitors.Semantic proximity Read ↗

Saccharomyces cerevisiae resistance to chlorinated phenoxyacetic acid herbicides involves Pdr1p-mediated transcriptional activation of TPO1 and PDR5 genes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.