Article
Phenotype of recombinant Trypanosoma cruzi which overexpress elongation factor 1-gamma: possible involvement of EF-1gamma GST-like domain in the resistance to clomipramine.
Gene - 1 Oct 1997
Billaut-Mulot O, Fernandez-Gomez R, Ouaissi A
Abstract excerpt
In previous studies, molecular and immunological approaches have been used to characterize the Trypansosoma cruzi elongation factor 1gamma (TcEF-1gamma). A primary sequence homology search revealed that the TcEF-1gamma N-terminal domain showed significant homology to glutathione S-transferases (GSTs). Although studies have suggested the involvement of EF-1gamma in the protein synthesis machinery, the exact...
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