Article
Characterization of the Saccharomyces cerevisiae RTA1 gene involved in 7-aminocholesterol resistance.
Current genetics - 31 Jul 1996
Soustre I, Letourneux Y, Karst F
Abstract excerpt
7-aminocholesterol has been described as being a strong inhibitor of yeast and of Gram+-bacteria proliferation. In order to determine the precise molecular target of the toxicity of this compound, we searched for yeast resistance linked to gene over-expression. We named the new yeast gene that was isolated RTA1 (EMBL X84736). This gene led to strong resistance to the inhibitor. Gene sequencing revealed that RTA1...
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