Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

[Antigenicity of major hydrophilic region II of hepatitis B virus surface antigen].

Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology - 1 Feb 2007

Tian Yong-jun, Zhang Zheng-mao, Xia Chang, Liu Shen-pei, Yu Yuan, Huang Hong-ping, Yang Yan, Lu Meng-ji, Yang Dong-liang

Abstract excerpt

OBJECTIVE: To study whether the substitutions at the major hydrophilic region II (MHRII) of hepatitis B surface antigen (HBsAg) will impair the antigenicity of HBsAg. METHODS: Four recombinant plasmids expressing mutant HBsAg (mtHBsAg) P1120T, C121S, K122I and T123N were constructed. HepG2 cells were transfected with the four plasmids and a plasmid expressing G145R HBsAg. The immunoreactivity of the cells...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Substitution
Share to Antigenic Variation

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Hep G2 Cells

Share to Hepatitis B Surface Antigens

Share to Hepatitis B virus

Share to Mutation

Share to Plasmids

Share to Transfection

Source

Identifiers

PMID: 17362631

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

[Antigenicity of major hydrophilic region II of hepatitis B virus surface antigen].PMID 17362631Read ↗

[Antigenic properties of mutant hepatitis B virus surface antigen].Semantic proximity Read ↗

[Functional analysis of hepatitis B virus immune escape mutants with insertion mutations in the surface antigen].Semantic proximity Read ↗

[Impact of amino acid sequence variation of a determinant(s) on the antigenic properties of hepatitis B virus HBsAg].Semantic proximity Read ↗

Investigation of a Novel Hepatitis B Virus Surface Antigen (HBsAg) Escape Mutant Affecting Immunogenicity.Semantic proximity Read ↗

[A comparative characteristic of antigenic properties of recombinant and native hbs-antigens with G145R mutation and evaluation of their immunogenicity].Semantic proximity Read ↗

Influence of mutations in hepatitis B virus surface protein on viral antigenicity and phenotype in occult HBV strains from blood donors.Semantic proximity Read ↗

Amino acid substitutions Q129N and T131N/M133T in hepatitis B surface antigen (HBsAg) interfere with the immunogenicity of the corresponding HBsAg or viral replication ability.Semantic proximity Read ↗

[Antigenic analysis of the common recombinant mutant types of HBsAg].Semantic proximity Read ↗

Construction and expression of hepatitis B surface antigen escape variants within the "a" determinant by site directed mutagenesis.Semantic proximity Read ↗

Molecular analysis of antigenicity and immunogenicity of a vaccine-induced escape mutant of hepatitis B virus.Semantic proximity Read ↗

[Expression of recombinant inserting mutants of HBsAg in vitro and its antigenic analysis].Semantic proximity Read ↗

Impacts of the G145R Mutation on the Structure and Immunogenic Activity of the Hepatitis B Surface Antigen: A Computational AnalysisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.