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Article

Investigation of a Novel Hepatitis B Virus Surface Antigen (HBsAg) Escape Mutant Affecting Immunogenicity.

PloS one - 1 Jan 2017

Hossain Md Golzar, Ueda Keiji

Abstract excerpt

Mutation in the hepatitis B virus surface antigen (HBsAg) may affect the efficiency of diagnostic immunoassays or success of vaccinations using HBsAg. Thus, antigenicity and immunogenicity analyses of the mutated HBsAg are necessary to develop novel diagnostic tools and efficient vaccinations. Here, the in vitro antigenicity of three wild-type HBsAg open reading frames (ORFs) (adr4, W1S [subtype adr] and W3S...

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Identifiers

PMID: 28045894
DOI: 10.1371/journal.pone.0167871
PMCID: PMC5207502

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