Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Impacts of the G145R Mutation on the Structure and Immunogenic Activity of the Hepatitis B Surface Antigen: A Computational Analysis

28 Jun 2016

Abstract excerpt

BACKGROUND: Vaccine-escaped hepatitis B virus (HBV) mutations occur within the "a" determinant area, which is located in the major hydrophilic region (MHR) of the hepatitis B surface antigen (HBsAg) protein. It is now well established that the common G145R mutation is highly capable of escaping from HBsAg immune recognition. However, the impacts of this mutation on the structure and immunogenic activity of HBsAg...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Hepatitis B Virus Studies
Share to Monoclonal and Polyclonal Antibodies Research
Share to vaccines and immunoinformatics approaches

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 27642350
DOI: 10.5812/hepatmon.39097

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Impacts of the G145R Mutation on the Structure and Immunogenic Activity of the Hepatitis B Surface Antigen: A Computational AnalysisPMID 27642350Read ↗

Construction and expression of hepatitis B surface antigen escape variants within the "a" determinant by site directed mutagenesis.Semantic proximity Read ↗

[Functional analysis of hepatitis B virus immune escape mutants with insertion mutations in the surface antigen].Semantic proximity Read ↗

Mutations of the surface protein of hepatitis B virus.Semantic proximity Read ↗

Deficiency in virion secretion and decreased stability of the hepatitis B virus immune escape mutant G145R.Semantic proximity Read ↗

[A comparative characteristic of antigenic properties of recombinant and native hbs-antigens with G145R mutation and evaluation of their immunogenicity].Semantic proximity Read ↗

In silico design of novel recombinant antigens containing immunologically relevant regions of wild-type and escape mutant variants of HBsAg.Semantic proximity Read ↗

Comprehensive analysis of the prevalence of hepatitis B virus escape mutations in the major hydrophilic region of surface antigen.Semantic proximity Read ↗

Mutations in the S gene region of hepatitis B virus genotype D in Golestan Province-Iran.Semantic proximity Read ↗

Characterization of a novel hepatitis B virus mutant: demonstration of mutation-induced hepatitis B virus surface antigen group specific "a" determinant conformation change and its application in diagnostic assays.Semantic proximity Read ↗

Effects of amino acid substitutions in hepatitis B virus surface protein on virion secretion, antigenicity, HBsAg and viral DNA.Semantic proximity Read ↗

Hepatitis B caused by a hepatitis B surface antigen escape mutant.Semantic proximity Read ↗

Analysis of HBs antigen negative variant of hepatitis B virus: unique substitutions, Glu129 to Asp and Gly145 to Ala in the surface antigen gene.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.