Article
[A comparative characteristic of antigenic properties of recombinant and native hbs-antigens with G145R mutation and evaluation of their immunogenicity].
Voprosy virusologii - 1 Jan 2017
Konopleva Maria V, Borisova V N, Sokolova M V, Feldsherova A A, Krymskij M A, Semenenko T A, Suslov A P
Abstract excerpt
BACKGROUND: One of the important reasons for spreading of hepatitis B virus (HBV) under conditions of vaccinepressure is emergence of escape mutations. Prevalent G145R mutation in S-gene leads to the most expressed changes of serological properties of HBV. Consequently, HBsAg is modifed so thoroughly that it cannot be recognized by the majority of anti-HBs. Mutant G145R also differs from a wild type HBsAg by its...
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