Article
Dsk1p kinase phosphorylates SR proteins and regulates their cellular localization in fission yeast.
The Biochemical journal - 1 Jul 2007
Tang Zhaohua, Tsurumi Amy, Alaei Sarah, Wilson Christopher, Chiu Cathleen, Oya Jessica, Ngo Benson
Abstract excerpt
Evolutionarily conserved SR proteins (serine/arginine-rich proteins) are important factors for alternative splicing and their activity is modulated by SRPKs (SR protein-specific kinases). We previously identified Dsk1p (dis1-suppressing protein kinase) as the orthologue of human SRPK1 in fission yeast. In addition to its similarity of gene structure to higher eukaryotes, fission yeast Schizosaccharomyces pombe is...
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