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Article

Evidence for disulfide bonds in SR Protein Kinase 1 (SRPK1) that are required for activity and nuclear localization.

PloS one - 1 Jan 2017

Koutroumani Maria, Papadopoulos Georgios E, Vlassi Metaxia, Nikolakaki Eleni, Giannakouros Thomas

Abstract excerpt

Serine/arginine protein kinases (SRPKs) phosphorylate Arg/Ser dipeptide-containing proteins that play crucial roles in a broad spectrum of basic cellular processes. The existence of a large internal spacer sequence that separates the bipartite kinase catalytic core is a unique structural feature of SRPKs. Previous structural studies on a catalytically active fragment of SRPK1, which lacks the main part of the...

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Identifiers

PMID: 28166275
DOI: 10.1371/journal.pone.0171328
PMCID: PMC5293202

Genes

SRPK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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