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Article

Prp4 Kinase Grants the License to Splice: Control of Weak Splice Sites during Spliceosome Activation.

PLoS genetics - 1 Jan 2016

Eckert Daniela, Andrée Nicole, Razanau Aleh, Zock-Emmenthal Susanne, Lützelberger Martin, Plath Susann, Schmidt Henning, Guerra-Moreno Angel, Cozzuto Luca, Ayté José, Käufer Norbert F

Abstract excerpt

The genome of the fission yeast Schizosaccharomyces pombe encodes 17 kinases that are essential for cell growth. These include the cell-cycle regulator Cdc2, as well as several kinases that coordinate cell growth, polarity, and morphogenesis during the cell cycle. In this study, we further characterized another of these essential kinases, Prp4, and showed that the splicing of many introns is dependent on Prp4...

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PMID: 26730850
DOI: 10.1371/journal.pgen.1005768
PMCID: PMC4701394

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Research trail→

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Prp4 Kinase Grants the License to Splice: Control of Weak Splice Sites during Spliceosome Activation.PMID 26730850Read ↗

SR protein kinases promote splicing of nonconsensus introns.Semantic proximity Read ↗

Activation of Prp28 ATPase by phosphorylated Npl3 at a critical step of spliceosome remodeling.Semantic proximity Read ↗

Isolation of an essential Schizosaccharomyces pombe gene, prp31(+), that links splicing and meiosis.Semantic proximity Read ↗

Genome-wide analysis of pre-mRNA splicing: intron features govern the requirement for the second-step factor, Prp17 in Saccharomyces cerevisiae and Schizosaccharomyces pombe.Semantic proximity Read ↗

The Fission Yeast Pre-mRNA-processing Factor 18 (prp18+) Has Intron-specific Splicing Functions with Links to G1-S Cell Cycle Progression.Semantic proximity Read ↗

Fission yeast Prp4p kinase regulates pre-mRNA splicing by phosphorylating a non-SR-splicing factor.Semantic proximity Read ↗

Distinct domains of splicing factor Prp8 mediate different aspects of spliceosome activation.Semantic proximity Read ↗

A cold-sensitive mRNA splicing mutant is a member of the RNA helicase gene family.Semantic proximity Read ↗

Regulation of constitutive and alternative mRNA splicing across the human transcriptome by PRPF8 is determined by 5' splice site strength.Semantic proximity Read ↗

Mutations within the yeast U4/U6 snRNP protein Prp4 affect a late stage of spliceosome assembly.Semantic proximity Read ↗

A connection between pre-mRNA splicing and the cell cycle in fission yeast: cdc28+ is allelic with prp8+ and encodes an RNA-dependent ATPase/helicase.Semantic proximity Read ↗

Competition between the ATPase Prp5 and branch region-U2 snRNA pairing modulates the fidelity of spliceosome assembly.Semantic proximity Read ↗

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