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Article

SR protein kinases promote splicing of nonconsensus introns.

Nature structural & molecular biology - 1 Aug 2015

Lipp Jesse J, Marvin Michael C, Shokat Kevan M, Guthrie Christine

Abstract excerpt

Phosphorylation of the spliceosome is essential for RNA splicing, yet how and to what extent kinase signaling affects splicing have not been defined on a genome-wide basis. Using a chemical genetic approach, we show in Schizosaccharomyces pombe that the SR protein kinase Dsk1 is required for efficient splicing of introns with suboptimal splice sites. Systematic substrate mapping in fission yeast and human cells...

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Identifiers

PMID: 26167880
DOI: 10.1038/nsmb.3057

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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