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Article

Loss of Aire-dependent thymic expression of a peripheral tissue antigen renders it a target of autoimmunity.

Proceedings of the National Academy of Sciences of the United States of America - 13 Mar 2007

Gavanescu Irina, Kessler Benedikt, Ploegh Hidde, Benoist Christophe, Mathis Diane

Abstract excerpt

Both humans and mice with a mutation in the autoimmune regulator (aire) gene develop multiorgan autoimmune disease. Aire was shown to exert its critical function in medullary epithelial cells of the thymus by promoting ectopic expression of peripheral tissue antigens. It was hypothesized that the...

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Identifiers

PMID: 17360567
DOI: 10.1073/pnas.0700259104
PMCID: PMC1838644

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-17360567-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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