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Article

Aire controls the differentiation program of thymic epithelial cells in the medulla for the establishment of self-tolerance.

The Journal of experimental medicine - 24 Nov 2008

Yano Masashi, Kuroda Noriyuki, Han Hongwei, Meguro-Horike Makiko, Nishikawa Yumiko, Kiyonari Hiroshi, Maemura Kentaro, Yanagawa Yuchio, Obata Kunihiko, Takahashi Satoru, Ikawa Tomokatsu, Satoh Rumi, Kawamoto Hiroshi, Mouri Yasuhiro, Matsumoto Mitsuru

Abstract excerpt

The roles of autoimmune regulator (Aire) in the expression of the diverse arrays of tissue-restricted antigen (TRA) genes from thymic epithelial cells in the medulla (medullary thymic epithelial cells [mTECs]) and in organization of the thymic microenvironment are enigmatic. We approached this is...

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Identifiers

PMID: 19015306
DOI: 10.1084/jem.20080046
PMCID: PMC2585853

Genes

TRA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19015306-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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