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Article

Evolutionarily conserved and divergent regions of the autoimmune regulator (Aire) gene: a comparative analysis.

Immunogenetics - 1 Feb 2008

Saltis Mark, Criscitiello Michael F, Ohta Yuko, Keefe Matthew, Trede Nikolaus S, Goitsuka Ryo, Flajnik Martin F

Abstract excerpt

During T cell differentiation, medullary thymic epithelial cells (MTEC) expose developing T cells to tissue-specific antigens. MTEC expression of such self-antigens requires the transcription factor autoimmune regulator (Aire). In mammals, defects in aire result in multi-tissue, T cell-mediated autoimmunity. Because the T cell receptor repertoire is randomly generated and extremely diverse in all jawed...

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Identifiers

PMID: 18214467
DOI: 10.1007/s00251-007-0268-9
PMCID: PMC7039057

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