Article
Aire-deficient C57BL/6 mice mimicking the common human 13-base pair deletion mutation present with only a mild autoimmune phenotype.
Journal of immunology (Baltimore, Md. : 1950) - 15 Mar 2009
Hubert François-Xavier, Kinkel Sarah A, Crewther Pauline E, Cannon Ping Z F, Webster Kylie E, Link Maire, Uibo Raivo, O'Bryan Moira K, Meager Anthony, Forehan Simon P, Smyth Gordon K, Mittaz Lauréane, Antonarakis Stylianos E, Peterson Pärt, Heath William R, Scott Hamish S
Abstract excerpt
Autoimmune regulator (AIRE) is an important transcription regulator that mediates a role in central tolerance via promoting the "promiscuous" expression of tissue-specific Ags in the thymus. Although several mouse models of Aire deficiency have been described, none has analyzed the phenotype induced by a mutation that emulates the common 13-bp deletion in human APECED (autoimmune...
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