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Article

Aire-deficient C57BL/6 mice mimicking the common human 13-base pair deletion mutation present with only a mild autoimmune phenotype.

Journal of immunology (Baltimore, Md. : 1950) - 15 Mar 2009

Hubert François-Xavier, Kinkel Sarah A, Crewther Pauline E, Cannon Ping Z F, Webster Kylie E, Link Maire, Uibo Raivo, O'Bryan Moira K, Meager Anthony, Forehan Simon P, Smyth Gordon K, Mittaz Lauréane, Antonarakis Stylianos E, Peterson Pärt, Heath William R, Scott Hamish S

Abstract excerpt

Autoimmune regulator (AIRE) is an important transcription regulator that mediates a role in central tolerance via promoting the "promiscuous" expression of tissue-specific Ags in the thymus. Although several mouse models of Aire deficiency have been described, none has analyzed the phenotype indu...

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Share to AIRE Protein
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mice, Inbred CBA

Share to Molecular Mimicry

Share to Mutagenesis, Site-Directed

Share to Polyendocrinopathies, Autoimmune

Share to Sequence Homology, Amino Acid

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Source

Identifiers

PMID: 19265170
DOI: 10.4049/jimmunol.0802124

Genes

AIRE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19265170-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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