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Article

Alteration of intra-pancreatic target-organ specificity by abrogation of Aire in NOD mice.

The Journal of clinical investigation - 1 May 2006

Niki Shino, Oshikawa Kiyotaka, Mouri Yasuhiro, Hirota Fumiko, Matsushima Akemi, Yano Masashi, Han Hongwei, Bando Yoshimi, Izumi Keisuke, Matsumoto Masaki, Nakayama Keiichi I, Kuroda Noriyuki, Matsumoto Mitsuru

Abstract excerpt

Factors that determine the spectrum of target organs involved in autoimmune destruction are poorly understood. Although loss of function of autoimmune regulator (AIRE) in thymic epithelial cells is responsible for autoimmunity, the pathogenic roles of AIRE in regulating target-organ specificity r...

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Source

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Identifiers

PMID: 16628255
DOI: 10.1172/JCI26971
PMCID: PMC1440703

Genes

AIRE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-16628255-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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Alteration of intra-pancreatic target-organ specificity by abrogation of Aire in NOD mice.PMID 16628255Read ↗

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