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Article

Independent effects of genetic variations in mannose-binding lectin influence the course of HIV disease: the advantage of heterozygosity for coding mutations.

The Journal of infectious diseases - 1 Jul 2008

Catano Gabriel, Agan Brian K, Kulkarni Hemant, Telles Vanessa, Marconi Vincent C, Dolan Matthew J, Ahuja Sunil K

Abstract excerpt

BACKGROUND: The in vivo impact of mannose-binding lectin (MBL), a molecule involved in innate immunity, on the pathogenesis of human immunodeficiency virus (HIV)-1 infection and AIDS is unknown. METHODS: A total of 1102 HIV-positive and 2213 HIV-negative adult subjects were screened for polymorphisms in the coding and promoter regions of MBL2, the gene that encodes MBL. RESULTS: Variations in MBL2 did not...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 18498240
DOI: 10.1086/588712
PMCID: PMC3777826

Genes

MBL2
CCR5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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