Article
Impact of mannose-binding lectin on susceptibility to infectious diseases.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America - 1 Dec 2003
Eisen Damon P, Minchinton Robyn M
Abstract excerpt
When the adaptive immune response is either immature or compromised, the innate immune system constitutes the principle defense against infection. Mannose-binding lectin (MBL) is a C-type serum lectin that plays a central role in the innate immune response. MBL binds microbial surface carbohydrates and mediates opsonophagocytosis directly and by activation of the lectin complement pathway. A wide variety of...
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