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Article

Mannose-binding lectin in susceptibility and progression of HIV-1 infection in children.

Antiviral therapy - 1 Jan 2006

Dzwonek Agnieszka, Novelli Vas, Bajaj-Elliott Mona, Turner Malcolm, Clapson Margaret, Klein Nigel

Abstract excerpt

BACKGROUND: Mannose-binding lectin (MBL; encoded by MBL-2) is a circulating pattern-recognition molecule that recognizes microbial carbohydrate motifs, leading to complement activation and cell lysis. Mutations in the MBL-2 promoter and of the MBL-2 gene exon 1 result in reduced protein levels and increased susceptibility to infection. We have investigated the effect of MBL-2 polymorphisms on susceptibility and...

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PMID: 16856624

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