Article
Infrequent mutation of the ras genes in skin tumors of xeroderma pigmentosum patients in Japan.
International journal of cancer - 1 Feb 1992
Ishizaki K, Tsujimura T, Nakai M, Nishigori C, Sato K, Katayama S, Kurimura O, Yoshikawa K, Imamura S, Ikenaga M
Abstract excerpt
By using PCR amplification and oligonucleotide mismatch hybridization, base-substitution mutations of the ras genes in 26 skin tumors of Japanese xeroderma pigmentosum (XP) patients were studied. Thin sections of tumor tissues which were fixed and embedded in paraffin blocks were used in this stu...
Topics
- Base Sequence
- Carcinoma
- Genes, ras
- Humans
- Molecular Sequence Data
- Mutation
- Oligodeoxyribonucleotides
- Oligonucleotide Probes
- Polymerase Chain Reaction
- Skin Neoplasms
- Xeroderma Pigmentosum