H-, K-, and N-ras gene mutation in atypical fibroxanthoma and malignant fibrous histiocytoma.

doi:10.1053/hupa.2001.28953

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H-, K-, and N-ras gene mutation in atypical fibroxanthoma and malignant fibrous histiocytoma.

Human pathology - 1 Nov 2001

Sakamoto A, Oda Y, Itakura E, Oshiro Y, Tamiya S, Honda Y, Ishihara A, Iwamoto Y, Tsuneyoshi M

Abstract excerpt

Atypical fibroxanthoma (AFX) which is histologically similar to malignant fibrous histiocytoma (MFH), occurs in the sun-exposed skin. The presence of mutations at codons 12 and 13 of the H- and K-ras genes and in exons 1 and 2, which include codons 12, 13, and 61, of the N-ras gene was studied in 8 cases of AFX and 8 cases of storiform-pleomorphic-type MFH using polymerase chain reaction (PCR)-restriction...

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H-, K-, and N-ras gene mutation in atypical fibroxanthoma and malignant fibrous histiocytoma.

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