Article
Ras gene mutation and amplification in human nonmelanoma skin cancers.
Molecular carcinogenesis - 1 Jan 1991
Pierceall W E, Goldberg L H, Tainsky M A, Mukhopadhyay T, Ananthaswamy H N
Abstract excerpt
Our previous studies have shown that human skin cancers occurring on sun-exposed body sites frequently contain activated Ha-ras oncogenes capable of inducing morphologic and tumorigenic transformation of NIH 3T3 cells. In this study, we analyzed human primary squamous cell carcinomas (SCCs) and basal cell carcinomas (BCCs) occurring on sun-exposed body sites for mutations in codons 12, 13, and 61 of Ha-ras,...
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