Article
Ras gene mutation and amplification in human nonmelanoma skin cancers.
Molecular carcinogenesis - 1 Jan 1991
Pierceall W E, Goldberg L H, Tainsky M A, Mukhopadhyay T, Ananthaswamy H N
Abstract excerpt
Our previous studies have shown that human skin cancers occurring on sun-exposed body sites frequently contain activated Ha-ras oncogenes capable of inducing morphologic and tumorigenic transformation of NIH 3T3 cells. In this study, we analyzed human primary squamous cell carcinomas (SCCs) and b...
Topics
- Adult
- Aged
- Aged, 80 and over
- Animals
- Base Sequence
- Carcinoma, Basal Cell
- Carcinoma, Squamous Cell
- Cell Line
- Female
- Gene Amplification
- Genes, ras
- Humans
- Immunoblotting
- Male
- Mice
- Middle Aged
- Molecular Sequence Data
- Mutation