Article
Far less frequent mutations in ras genes than in the p53 gene in skin tumors of xeroderma pigmentosum patients.
Molecular carcinogenesis - 1 Oct 1994
Sato M, Nishigori C, Lu Y, Zghal M, Yagi T, Takebe H
Abstract excerpt
Mutations in Ha-ras, Ki-ras, and N-ras genes in squamous and basal cell carcinomas in patients with xeroderma pigmentosum (XP) were examined by the polymerase chain reaction followed by single-strand conformation polymorphism analysis and direct base sequencing. No mutation was detected in codons...
Topics
- 3T3 Cells
- Adolescent
- Adult
- Animals
- Base Sequence
- Carcinoma, Basal Cell
- Carcinoma, Squamous Cell
- Child
- Genes, p53
- Genes, ras
- Humans
- Mice
- Molecular Sequence Data
- Mutation
- Polymorphism, Single-Stranded Conformational
- Skin Neoplasms
- Xeroderma Pigmentosum