Article
Far less frequent mutations in ras genes than in the p53 gene in skin tumors of xeroderma pigmentosum patients.
Molecular carcinogenesis - 1 Oct 1994
Sato M, Nishigori C, Lu Y, Zghal M, Yagi T, Takebe H
Abstract excerpt
Mutations in Ha-ras, Ki-ras, and N-ras genes in squamous and basal cell carcinomas in patients with xeroderma pigmentosum (XP) were examined by the polymerase chain reaction followed by single-strand conformation polymorphism analysis and direct base sequencing. No mutation was detected in codons 12, 13, and 61 of the ras genes in XP skin tumors. This was in contrast with previous findings of a high frequency of...
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