Article
High mutation frequency in ras genes of skin tumors isolated from DNA repair deficient xeroderma pigmentosum patients.
Cancer research - 1 Apr 1993
Daya-Grosjean L, Robert C, Drougard C, Suarez H, Sarasin A
Abstract excerpt
Xeroderma pigmentosum (XP) patients are clinically characterized by a very high incidence of skin cancers on exposed skin, at an early age. XP cells in vitro are strongly deficient in excision-repair and highly mutagenized by UV light. We were, therefore, interested in measuring mutation frequency and in determining mutation spectra in patients' tumors exposed to UV lesions. We chose to look at oncogene...
Topics
- Base Sequence
- Blotting, Southern
- Carcinoma, Basal Cell
- Carcinoma, Squamous Cell
- DNA Repair
- Gene Amplification
- Genes, myc
- Genes, ras
- Humans
- Melanoma
- Molecular Sequence Data
- Mutation
- Nucleic Acid Amplification Techniques
- Polymerase Chain Reaction
- Skin Neoplasms
- Xeroderma Pigmentosum