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Article

Mechanism of actin network attachment to moving membranes: barbed end capture by N-WASP WH2 domains.

Cell - 9 Mar 2007

Co Carl, Wong Derek T, Gierke Sarah, Chang Vicky, Taunton Jack

Abstract excerpt

Actin filament networks exert protrusive and attachment forces on membranes and thereby drive membrane deformation and movement. Here, we show that N-WASP WH2 domains play a previously unanticipated role in vesicle movement by transiently attaching actin filament barbed ends to the membrane. To dissect the attachment mechanism, we reconstituted the propulsive motility of lipid-coated glass beads, using purified...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 17350575
DOI: 10.1016/j.cell.2006.12.049
PMCID: PMC2047291

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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