Article
Requirement of the basic region of N-WASP/WAVE2 for actin-based motility.
Biochemical and biophysical research communications - 6 Apr 2001
Suetsugu S, Miki H, Yamaguchi H, Takenawa T
Abstract excerpt
WASP family proteins activate nucleation by the Arp2/3 complex, inducing rapid actin polymerization in vitro. Although the C-terminal portion of WASP family proteins (VCA) activates nucleation by the Arp2/3 complex in pure systems, we find that this fragment lacks activity in cell extracts. Thus, polystyrene beads coated with VCA did not move in brain cytosol, while beads coated with N-WASP or WAVE2 did move. The...
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